Diet high in sugar primes brain for drug dependence

Ontario, Canada (BBN) – Could a diet high in refined sugars make children and adults more susceptible to opioid addiction and overdose?

New research, from our laboratory of behavioral neuroscience at the University of Guelph, suggests it could, reports Daily Mail.

Approximately 20,000 people died of fentanyl-related overdoses in the US last year and in Canada there were at least 2,816 opioid-related deaths.

During 2017, so far, over 1,000 people have died of illicit drug overdoses in British Columbia.

High schools are stocking up on the overdose-reversing drug naloxone and universities are training staff to administer the drug.

Nobody is talking about sugar.

And yet there is substantial experimental evidence that refined sugar can promote addictive behaviors by activating the brain’s rewards centers in much the same way as addictive drugs.

Opioid abuse is also associated with poor dietary habits, including preferences for sugar-rich foods, as well as malnutrition.

These connections have led to questions of whether excessive consumption of refined sugar may affect vulnerability to opioid addiction.

To explore the possible role of a sugar-rich diet in opioid addiction, we investigated whether unlimited access to high fructose corn syrup (HFCS) altered rats’ neural and behavioral responses to the semi-synthetic opioid, oxycodone.

Our findings suggest that a diet high in corn syrup may dampen the reward associated with oxycodone and may therefore encourage consumption of higher quantities of the drug.

High fructose corn syrup is a refined sugar that typically includes more fructose than glucose.

It is a commonly used food additive in North America, produced by chemically processed corn.

Although it is employed in many processed foods, its use in soft drinks appears to have the biggest impact on health.

In fact, there is a significant relationship between increased consumption of sugar-sweetened beverages and weight gain, metabolic syndrome and hypertension.

Recently, our laboratory has been exploring the impact of HFCS on behaviors and brain markers of addiction in laboratory rats.

The legal versions of fentanyl are prescribed to alleviate severe pain associated with advanced cancer.

Illegally-made fentanyl, which can be ordered from China or bought from Mexico, is often mixed with heroin or cocaine.

Other names for the drug purchased on the dark web or from a trafficker include:

In one study conducted by my PhD student Meenu Minhas, animals had unrestricted around-the-clock access to bottles containing a water solution sweetened by HFCS.

After about a month of voluntary drinking, the bottles were removed and, after a few sugar-free days, animals’ behavioral and neural responses to oxycodone were assessed.

Similar to other opioids, oxycodone induces pharmacological effects that include analgesia, euphoria and feelings of relaxation. Some common street names include: ‘hillbilly heroin’, ‘perc’, and ‘OC’.

Oxycodone is the active ingredient in a number of formulations which include intravenous injections, immediate release solutions/capsules (Percocet, Percodan, OXY IR, OXY FAST), and extended release preparations (OxyContin).

Oxycodone is also highly addictive and has impacted the lives of numerous North Americans. There are estimates that its consumption increased by almost 500 percent from 1999 to 2011.

The US National Survey on Drug Use and Health revealed that approximately 27.9 million people aged 12 or older used oxycodone products.

Moreover, 4.3 million people aged 12 or older reported misusing oxycodone-containing products in the past year.

DAMPENING DRUG’S REWARD MAY INCREASE USE

At the neural level, HFCS exposure decreased oxycodone-induced release of dopamine, which is a desire-promoting neurotransmitter active in the brain’s reward circuits.

Furthermore, at low doses, sedative drugs like opioids and alcohol normally interfere with inhibition and stimulate a variety of ‘psychomotor’ behaviors – such as sociability, extroversion, talkativeness, sensation seeking and interest in novelty.

Our study in rats found that exposure to the high fructose corn syrup reduced this psychomotor stimulation induced by oxycodone.

Our experiments show that chronic exposure to high fructose corn syrup had an impact on both the neural and behavioral responses to oxycodone, resulting in changes likely to affect drug-taking and drug-seeking behavior.

They suggest that a high sugar diet may dampen the reward associated with a given dose of oxycodone. And that this may cause people to consume more of the drug.

These results suggest that nutrition, and high fructose corn syrup intake in particular, can influence responses to opioids – a finding that may be relevant both to clinical uses of opioids and to treatment of addiction.

We can win the war on opioid addiction only if we tackle the problem from multiple angles.

Our findings, and those of other laboratories, strongly suggest that prevention of unhealthy diets may not only help reduce the obesity epidemic, but also reduce environmental factors that may predispose to opioid addiction.

BBN/SS/AD