California, US (BBN)-Hewlett-Packard said it plans to cut between 25,000 and 30,000 jobs.
The move is part of an effort to split the company into two units, which is set to take place in November, reports BBC.
The losses will come in Hewlett Packard Enterprise, which is splitting from the firm's printer and personal computer business.
The company says the cuts will save it $2.7bn (£1.76bn) in annual costs, but it will take a $2.7bn charge to execute the plan.
At a meeting for Wall Street analysts, chairman and chief executive Meg Whitman said: "We've done a significant amount of work over the past few years to take costs out and simplify processes and these final actions will eliminate the need for any future corporate restructuring."
The tech company has struggled over the last decade to keep up with changing demands as customers move away from desktop computers.
It already plans to lay off 55,000 employees as part of the restructuring process that started in 2012.
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